600), which attempted to amass the entire medical knowledge, with special focus on surgery; and the two-volume tome comprising Astanga Samgraha and Astanga Hridaya (c.130-200 A.D.), written by Vagbhata the Elder and Vagbhata the Younger, which synthesized the works of Charaka and Susruta and summarized the eight parts of Ayurveda in prose and verse forms. However, two AKBA-containing compounds, Alfapin and 5-Loxin, have good bioavailability.138 Boswellia resin has been shown to improve clinical signs and pain in humans in controlled studies.139-141 Boswellia resin has been evaluated in 24 dogs in an open multicenter study.142 Improvement in clinical signs, lameness, and pain was found in 17 of 24 dogs.
Palmowski MJ, Brandt KD. Salai guggul (from. These have also been used as adhesives, as ingredients for cosmetic preparations, as fragrances in daily rituals and in religious ceremonies, as coating materials and also for their different curative powers[13].
(Chapu-de-couro), Colchicum luteum Baker (Suranjan-Talkh), Tripterygium wilfordii Hook F. (Thunder God Vine), Andrographis paniculata (Burm. It inhibits MMP-3, an enzyme that breaks down cartilage, collagen, and connective tissue. (turmeric), Cinnamomum zeylanicum Blume (cinnamon), Echinodorus grandiflorus (Cham. -Boswellic acid can downregulate the synthesis of prostaglandins by inhibiting COX-1 in intact human platelets (Siemoneit et al., 2008). Chatterjee GK, Pal SD. The https:// ensures that you are connecting to the
Incensole acetate, a novel antiinflammatory compound isolated from Boswellia resin inhibits nuclear factor-kappa B activation[58]. Modern medicine and pharmacology strongly point out to its use as an antiarthritic, antiinflammatory, antihyperlipidemic (controls blood lipids), antiatherosclerotic (anticoronary plaque), analgesic (pain-reliever) and hepatoprotective (protects the liver)[15,2124]. Resin from the bark of this tree is purported to have antiinflammatory properties derived primarily from 3-O-acetyl-11-keto--boswellic acid (AKBA), which inhibits 5-lipoxygenase and matrix metalloproteinases, and decreases tumor necrosis factor and interleukin 1.136,137 Following oral administration, AKBA has poor bioavailability. 38991. Since ancient times, three of these species have been considered as true Frankincense producing trees[9,10]. It is also diaphoretic, astringent, diuretic and acts both as internal and external stimulant. Treatment of osteoarthritis with a herbomineral formulation: A double blind, placebo-controlled, cross-over study. Arora RB, Kapoor V, Basu N, Jain AP. Gum-resin extracts of Boswellia serrata have been traditionally used in folk medicine for centuries to treat various chronic inflammatory diseases. government site. A novel herbal composition LI13109F, containing extracts of B. serrata gum resin and Aegle marmelos fruit, improved asthma symptoms by reducing IL-4 levels and increasing IFN- in a double-blind controlled clinical trial (Kaluza et al., 2018). Ammon HP. Taken together, these results demonstrate the broad spectrum safety of Boswellia (Lalithakumari et al., 2006). There are about 25 known species belonging to Genus Boswellia, most of them occur in Arabia, northeastern coast of Africa and India. Baliga, in Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases, 2013. Sharma S, Thawani V, Hingorani L. Pharmacokinetic study of 11-keto-beta-boswellic acid. Oleo gum-resin is tapped from the incision made on the trunk of the tree and is then stored in specially made bamboo basket for removal of oil content and getting the resin solidified. Despite its historical, religious, cultural and medicinal importance, Boswellia has not been thoroughly studied, and gaps still exist between our knowledge of the traditional uses of the resin and the scientific data available. Diego P. de Oliveira, Mauro M. Teixeira, in Inflammation and Natural Products, 2021. Kulkarni R, Patki P, Jog V, Gandage S, Patwardhan B. In India, the States of Andhra Pradesh, Gujarat, Madhya Pradesh, Jharkhand and Chhattisgarh are the main source of Boswellia serrata. Figure 13.5. Boswellia carterii Birdw, grows in Somalia and in the native language it is called moxor and the resin produced is known as luban dhakar. Singh GB, Atal CK. about navigating our updated article layout. Another resin producing species is Boswellia serrata Roxb., known as Indian olibanum, Indian frankincense, dhup and salai or salai guggul is found in the middle and northern parts of Eastern India. Traditional Indian Ayurvedic system of medicine referred Boswellia as Salai guggul in Ayurvedic literatures like Charaka Samhita in 1st and 2nd century AD for the treatment of various disorders [3]. 5-Loxin (a patent-pending product of PLT Health Solutions, Inc.), with 30% AKBA as its active ingredient, provides improvement in joint mobility and comfort within 1 week. We use cookies to help provide and enhance our service and tailor content and ads. Herbal raw material and traditional remedies. The Boswellia serrata plant is native to India, and its extract has been used as a traditional medicine for centuries. The oleo gum-resins contain 30-60% resin, 5-10% essential oils, which are soluble in the organic solvents, and the rest is made up of polysaccharides. Boswellia tree can produce exudates in good quality only for three years. Acetyl-11-keto--boswellic acid inhibits prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis. Boswellia sacra Flueck, the first species, grows in South Arabia and is known amongst Arabians as maghrayt d sheehaz and the resin produced is known as luban dhakar. The .gov means its official. Boswellia serrata is a plant that produces Indian frankincense. Clinical study results suggest that B. serrata extract has potential benefit for asthma patients (Gupta et al., 1998). Pharmacopoeia of India, Govt. Tetracyclic triterpene acids from the resin of, Pardhy RS, Bhattacharyya SC. Chopra A, Lavin P, Patwardhan B, Chitre D. Randomized double blind trial of an Ayurvedic plant derived formulation for treatment of rheumatoid arthritis. The essential oil of gum-resin is one of the most commonly used oils in aromatherapy, paints and varnishes. Howes FN. Effect of salicylates and other non-steroidal anti-inflammatory drugs on articular cartilage. Cincinnati: Ohio Valley Company, US; 1898. 14th ed. Other antiinflammatory plant constituents, such as quercetin, also block this enzyme, but they do so in a more general fashion, as an antioxidant, whereas boswellic acids seem to be specific inhibitor of 5-LO[39]. There were few adverse effects. Boswellia serrata is a medium to large-sized branching tree of the boswellia genus. Pang X, Yi Z, Zhang X, Sung B, Qu W, Lian X, et al. Encyclopedia of common natural ingredients used in food, drugs and cosmetics; pp. 1 and Table 2, respectively[32]. The site is secure. Hall, R. Bravo-Clouzet, in Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases, 2013. The genetic basis of the anti-inflammatory effects of Boswellia was explored in a system of TNF-induced gene expression in human microvascular endothelial cells. Basch E, Boon H, Davies T, Hashmi S, Hasskari J, Sollars D, et al. Khare CP. fil.) BOTANICAL ORIGIN AND VERNACULAR NAMES OF BOSWELLIA SERRATA. Boswellia frereana Birdw., is also a Somalian species and in the native language it is called jagcaar and the resin produced is known as loban majdi or maydi. The active constituents of the gum resin are boswellic acids. D.M. On the interference of boswellic acids with 5-lipoxygenase: Mechanistic studies. New York: Churchill Livingston; 2002. In 30 patients aged 1848 years with chronic colitis, characterized by vague lower abdominal pain, rectal bleeding, diarrhea, and palpable tender descending and sigmoid colons, Boswellia serrata (900mg/day for 6 weeks) produced remission in 14 of 20 patients, and sulfasalazine (3g/day for 6 weeks) in 4 of 10 patients [4]. Age-old resins of the Mediterranean region and their uses. [4], "Oral herbal therapies for treating osteoarthritis", https://en.wikipedia.org/w/index.php?title=Boswellia_serrata&oldid=1096469032, Creative Commons Attribution-ShareAlike License 3.0, This page was last edited on 4 July 2022, at 17:29. It has been available as a high quality extract in India for nearly 25 years and marketed under the name Shallaki. Major herbs of Ayurveda. Inhibition by boswellic acids of human leucocyte elastase. Natural products have many scientific superiorities like low side effects and assured biological activities. Ayurvedic Pharmacopoeia. Anti-arthritic activity of boswellic acids in bovine serum albumin (BSA)-induced arthritis. 75/- and the dose is 1 capsule twice daily (Batch No. The antiinflammatory action of Indian medicinal plants. By continuing you agree to the use of cookies.
Superfine, Grade I, Grade II and Grade III are available in the market. Boswellia supplementation did not cause changes in hepatic DNA fragmentation on 30, 60 or 90 days of treatment. Handa SS. Singh et al. It reduces the activity of the enzyme tyrosinase within the skin, thus diminishing the production of melanin, which results in the reduction of dark skin formation. For this reason, in the last 20 years olibanum has gained increasing attention from scientists to better define its medicinal effects and identify the constituents responsible for these effects. The resinous part of Boswellia serrata possesses monoterpenes, diterpenes, triterpenes, tetracyclic triterpenic acids and four major pentacyclic triterpenic acids i.e. An official website of the United States government. The effect of anti-inflammatory drugs on glycosaminoglycan sulphation in pig cartilage. Constituents of gum obtained from, Gangwal ML, Vardhan DK. Products containing boswellic acids range from 150-250 mgs/capsules or tablets, and are taken orally two to three times a day. Indian herb hope for arthritis relief. A dose-dependent 90-day subchronic toxicity study demonstrated no significant changes in selected organ weights individually and as percentages of body and brain weights.
Diarrhea and flatulence occurred in five dogs. Rheumatic-X, contains 20 mg Shallaki besides a number of ingredients, manufactured by Sunrise Herbals, Varanasi (U.P., India), meant for rheumatoid, gouty, osteoarthritis and sciatic pain, two capsules twice daily or as directed by the physician. 5-Loxin provided significant benefits in WOMAC, Huskissons visual analog scale (VAS), and Lequesnes functional index (LFI) standardized testing methodologies for joint health. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. have reported clinical trials of Boswellia's antiinflammatory properties in combination with Withania somnifera, Zingiber officinate and Curcuma longa and the isolated effects of Boswellia on rheumatoid arthritis could not be revealed[50,51]. London: J and A Churchill Limited; 1967. Burning of these natural resins had become an important component of their cultural life. [56] have reported the effect of boswellic acids on bovine serum albumin (BSA)-induced arthritis in rabbits. Vol. Mechanism of anti-inflammatory actions of curcumine and boswellic acids. Indian Journal of Pharmaceutical Sciences. Three renowned ancient texts form the pillars of classical Ayurvedic Science, which has its roots in India: Charaka's Charaka Samhita (c.B.C. Its medicinal properties are also widely recognized, mainly for the treatment of inflammatory conditions, as well as in some cancerous diseases, wound healing and its antimicrobial activity. The website of the company is www.himalayahealthcare.com.
The resins have a fragrant aroma because of the presence of essential oils and this accounts for their commercial importance. Sharma ML, Bani S, Singh GB. The gum contains substances that have anti-inflammatory properties, pentacyclic triterpenes related to boswellic acid, which inhibit leukotriene biosynthesis in neutrophilic granulocytes by inhibiting 5-lipoxygenase. Copyright 2022 Elsevier B.V. or its licensors or contributors. In a double-blind, placebo-controlled study in 40 patients, aged 1875 years, with bronchial asthma, who were given Boswellia serrata 300mg tds for 6 weeks, 28 had improved dyspnea, a reduced number of attacks, increases in FEV1, FVC, and peak flow, and reduced eosinophil counts and ESR [2].
Palmowski MJ, Brandt KD. Salai guggul (from. These have also been used as adhesives, as ingredients for cosmetic preparations, as fragrances in daily rituals and in religious ceremonies, as coating materials and also for their different curative powers[13].
(Chapu-de-couro), Colchicum luteum Baker (Suranjan-Talkh), Tripterygium wilfordii Hook F. (Thunder God Vine), Andrographis paniculata (Burm. It inhibits MMP-3, an enzyme that breaks down cartilage, collagen, and connective tissue. (turmeric), Cinnamomum zeylanicum Blume (cinnamon), Echinodorus grandiflorus (Cham. -Boswellic acid can downregulate the synthesis of prostaglandins by inhibiting COX-1 in intact human platelets (Siemoneit et al., 2008). Chatterjee GK, Pal SD. The https:// ensures that you are connecting to the
Incensole acetate, a novel antiinflammatory compound isolated from Boswellia resin inhibits nuclear factor-kappa B activation[58]. Modern medicine and pharmacology strongly point out to its use as an antiarthritic, antiinflammatory, antihyperlipidemic (controls blood lipids), antiatherosclerotic (anticoronary plaque), analgesic (pain-reliever) and hepatoprotective (protects the liver)[15,2124]. Resin from the bark of this tree is purported to have antiinflammatory properties derived primarily from 3-O-acetyl-11-keto--boswellic acid (AKBA), which inhibits 5-lipoxygenase and matrix metalloproteinases, and decreases tumor necrosis factor and interleukin 1.136,137 Following oral administration, AKBA has poor bioavailability. 38991. Since ancient times, three of these species have been considered as true Frankincense producing trees[9,10]. It is also diaphoretic, astringent, diuretic and acts both as internal and external stimulant. Treatment of osteoarthritis with a herbomineral formulation: A double blind, placebo-controlled, cross-over study. Arora RB, Kapoor V, Basu N, Jain AP. Gum-resin extracts of Boswellia serrata have been traditionally used in folk medicine for centuries to treat various chronic inflammatory diseases. government site. A novel herbal composition LI13109F, containing extracts of B. serrata gum resin and Aegle marmelos fruit, improved asthma symptoms by reducing IL-4 levels and increasing IFN- in a double-blind controlled clinical trial (Kaluza et al., 2018). Ammon HP. Taken together, these results demonstrate the broad spectrum safety of Boswellia (Lalithakumari et al., 2006). There are about 25 known species belonging to Genus Boswellia, most of them occur in Arabia, northeastern coast of Africa and India. Baliga, in Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases, 2013. Sharma S, Thawani V, Hingorani L. Pharmacokinetic study of 11-keto-beta-boswellic acid. Oleo gum-resin is tapped from the incision made on the trunk of the tree and is then stored in specially made bamboo basket for removal of oil content and getting the resin solidified. Despite its historical, religious, cultural and medicinal importance, Boswellia has not been thoroughly studied, and gaps still exist between our knowledge of the traditional uses of the resin and the scientific data available. Diego P. de Oliveira, Mauro M. Teixeira, in Inflammation and Natural Products, 2021. Kulkarni R, Patki P, Jog V, Gandage S, Patwardhan B. In India, the States of Andhra Pradesh, Gujarat, Madhya Pradesh, Jharkhand and Chhattisgarh are the main source of Boswellia serrata. Figure 13.5. Boswellia carterii Birdw, grows in Somalia and in the native language it is called moxor and the resin produced is known as luban dhakar. Singh GB, Atal CK. about navigating our updated article layout. Another resin producing species is Boswellia serrata Roxb., known as Indian olibanum, Indian frankincense, dhup and salai or salai guggul is found in the middle and northern parts of Eastern India. Traditional Indian Ayurvedic system of medicine referred Boswellia as Salai guggul in Ayurvedic literatures like Charaka Samhita in 1st and 2nd century AD for the treatment of various disorders [3]. 5-Loxin (a patent-pending product of PLT Health Solutions, Inc.), with 30% AKBA as its active ingredient, provides improvement in joint mobility and comfort within 1 week. We use cookies to help provide and enhance our service and tailor content and ads. Herbal raw material and traditional remedies. The Boswellia serrata plant is native to India, and its extract has been used as a traditional medicine for centuries. The oleo gum-resins contain 30-60% resin, 5-10% essential oils, which are soluble in the organic solvents, and the rest is made up of polysaccharides. Boswellia tree can produce exudates in good quality only for three years. Acetyl-11-keto--boswellic acid inhibits prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis. Boswellia sacra Flueck, the first species, grows in South Arabia and is known amongst Arabians as maghrayt d sheehaz and the resin produced is known as luban dhakar. The .gov means its official. Boswellia serrata is a plant that produces Indian frankincense. Clinical study results suggest that B. serrata extract has potential benefit for asthma patients (Gupta et al., 1998). Pharmacopoeia of India, Govt. Tetracyclic triterpene acids from the resin of, Pardhy RS, Bhattacharyya SC. Chopra A, Lavin P, Patwardhan B, Chitre D. Randomized double blind trial of an Ayurvedic plant derived formulation for treatment of rheumatoid arthritis. The essential oil of gum-resin is one of the most commonly used oils in aromatherapy, paints and varnishes. Howes FN. Effect of salicylates and other non-steroidal anti-inflammatory drugs on articular cartilage. Cincinnati: Ohio Valley Company, US; 1898. 14th ed. Other antiinflammatory plant constituents, such as quercetin, also block this enzyme, but they do so in a more general fashion, as an antioxidant, whereas boswellic acids seem to be specific inhibitor of 5-LO[39]. There were few adverse effects. Boswellia serrata is a medium to large-sized branching tree of the boswellia genus. Pang X, Yi Z, Zhang X, Sung B, Qu W, Lian X, et al. Encyclopedia of common natural ingredients used in food, drugs and cosmetics; pp. 1 and Table 2, respectively[32]. The site is secure. Hall, R. Bravo-Clouzet, in Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases, 2013. The genetic basis of the anti-inflammatory effects of Boswellia was explored in a system of TNF-induced gene expression in human microvascular endothelial cells. Basch E, Boon H, Davies T, Hashmi S, Hasskari J, Sollars D, et al. Khare CP. fil.) BOTANICAL ORIGIN AND VERNACULAR NAMES OF BOSWELLIA SERRATA. Boswellia frereana Birdw., is also a Somalian species and in the native language it is called jagcaar and the resin produced is known as loban majdi or maydi. The active constituents of the gum resin are boswellic acids. D.M. On the interference of boswellic acids with 5-lipoxygenase: Mechanistic studies. New York: Churchill Livingston; 2002. In 30 patients aged 1848 years with chronic colitis, characterized by vague lower abdominal pain, rectal bleeding, diarrhea, and palpable tender descending and sigmoid colons, Boswellia serrata (900mg/day for 6 weeks) produced remission in 14 of 20 patients, and sulfasalazine (3g/day for 6 weeks) in 4 of 10 patients [4]. Age-old resins of the Mediterranean region and their uses. [4], "Oral herbal therapies for treating osteoarthritis", https://en.wikipedia.org/w/index.php?title=Boswellia_serrata&oldid=1096469032, Creative Commons Attribution-ShareAlike License 3.0, This page was last edited on 4 July 2022, at 17:29. It has been available as a high quality extract in India for nearly 25 years and marketed under the name Shallaki. Major herbs of Ayurveda. Inhibition by boswellic acids of human leucocyte elastase. Natural products have many scientific superiorities like low side effects and assured biological activities. Ayurvedic Pharmacopoeia. Anti-arthritic activity of boswellic acids in bovine serum albumin (BSA)-induced arthritis. 75/- and the dose is 1 capsule twice daily (Batch No. The antiinflammatory action of Indian medicinal plants. By continuing you agree to the use of cookies.
Superfine, Grade I, Grade II and Grade III are available in the market. Boswellia supplementation did not cause changes in hepatic DNA fragmentation on 30, 60 or 90 days of treatment. Handa SS. Singh et al. It reduces the activity of the enzyme tyrosinase within the skin, thus diminishing the production of melanin, which results in the reduction of dark skin formation. For this reason, in the last 20 years olibanum has gained increasing attention from scientists to better define its medicinal effects and identify the constituents responsible for these effects. The resinous part of Boswellia serrata possesses monoterpenes, diterpenes, triterpenes, tetracyclic triterpenic acids and four major pentacyclic triterpenic acids i.e. An official website of the United States government. The effect of anti-inflammatory drugs on glycosaminoglycan sulphation in pig cartilage. Constituents of gum obtained from, Gangwal ML, Vardhan DK. Products containing boswellic acids range from 150-250 mgs/capsules or tablets, and are taken orally two to three times a day. Indian herb hope for arthritis relief. A dose-dependent 90-day subchronic toxicity study demonstrated no significant changes in selected organ weights individually and as percentages of body and brain weights.
Diarrhea and flatulence occurred in five dogs. Rheumatic-X, contains 20 mg Shallaki besides a number of ingredients, manufactured by Sunrise Herbals, Varanasi (U.P., India), meant for rheumatoid, gouty, osteoarthritis and sciatic pain, two capsules twice daily or as directed by the physician. 5-Loxin provided significant benefits in WOMAC, Huskissons visual analog scale (VAS), and Lequesnes functional index (LFI) standardized testing methodologies for joint health. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. have reported clinical trials of Boswellia's antiinflammatory properties in combination with Withania somnifera, Zingiber officinate and Curcuma longa and the isolated effects of Boswellia on rheumatoid arthritis could not be revealed[50,51]. London: J and A Churchill Limited; 1967. Burning of these natural resins had become an important component of their cultural life. [56] have reported the effect of boswellic acids on bovine serum albumin (BSA)-induced arthritis in rabbits. Vol. Mechanism of anti-inflammatory actions of curcumine and boswellic acids. Indian Journal of Pharmaceutical Sciences. Three renowned ancient texts form the pillars of classical Ayurvedic Science, which has its roots in India: Charaka's Charaka Samhita (c.B.C. Its medicinal properties are also widely recognized, mainly for the treatment of inflammatory conditions, as well as in some cancerous diseases, wound healing and its antimicrobial activity. The website of the company is www.himalayahealthcare.com.
The resins have a fragrant aroma because of the presence of essential oils and this accounts for their commercial importance. Sharma ML, Bani S, Singh GB. The gum contains substances that have anti-inflammatory properties, pentacyclic triterpenes related to boswellic acid, which inhibit leukotriene biosynthesis in neutrophilic granulocytes by inhibiting 5-lipoxygenase. Copyright 2022 Elsevier B.V. or its licensors or contributors. In a double-blind, placebo-controlled study in 40 patients, aged 1875 years, with bronchial asthma, who were given Boswellia serrata 300mg tds for 6 weeks, 28 had improved dyspnea, a reduced number of attacks, increases in FEV1, FVC, and peak flow, and reduced eosinophil counts and ESR [2].